Top 6 Safety Data Sheet Software of 2024

a chemical bottle with a safety data sheet as a safety requirement being inspected using a safety data sheet software|3E Protect Safety Data Sheet Software|BackPack by Chemwatch Safety Data Sheet Software|Labelmaster Safety Data Sheet Software|SpheraCloud Safety Data Sheet Software|VelocityEHS Safety Data Sheet Software

Why use SafetyCulture?

This top-rated digital solutions provider offers one of the most effective safety data sheet (SDS) software, helping companies to digitize, organize, and disseminate information about chemical compounds, their hazards, and precautions to take when working with them. With its wide array of features, SafetyCulture safeguards the health and safety of workers in high-risk settings and ensures the company’s compliance with OSHA and Lab Safety standards.


  • Create electronic safety data sheets and organize the data collected in a central database, easily retrievable when required.
  • Use relevant checklists while doing routine inspections and audits in compliance with mandated regulations.
  • Raise issues and immediately assign preventive or corrective actions.
  • Generate reports about chemical hazards and the steps taken to mitigate or correct the problem and add media attachments to provide the full context of the incident.
  • Provide instruction or training to employees so they can understand and interpret SDS information.

Why use SpheraCloud?

SpheraCloud’s chemical data management solutions help companies ensure safety in the workplace and compliance with regulations through easy-to-use and update safety data sheets and optimize operations through automated processes.


  • Easy-access data
  • Automated reporting
  • End-to-end visibility

Why use BackPack?

This digital platform provides comprehensive solutions for managing chemicals efficiently, from use and storage to transport for disposal. They have a large chemical database that undergoes continuous updates to ensure companies using their system are at par with standards and abide by regulations.


  • SDS management
  • Registers and manifest
  • Reporting with documentation

Why use VelocityEHS?

This chemical and SDS software helps companies manage hazardous chemicals, from organizing them in a database, properly labeling them on-site, tracking their location, and comprehensive reporting. They also provide a HazCom e-book available to employees so they know how to handle these substances.


  • Inventory tracking with auto-updates
  • SDS offline access
  • Regulatory reporting

Why use Labelmaster?

An industry-leading digital solution for hazard communication, this helps companies safely operate in high-risk sites and conditions and ensure compliance with changing regulations. Aside from their comprehensive software features, they also offer safety products (e.g., storage containers, labels, placards, etc.), employee training, and site inspections.


  • Identification and classification
  • Regulatory monitoring
  • Compliance assessments

Why use 3E Protect?

This SDS and chemical management software is an award-winning digital solution that improves the health and safety situation of the workforce by decreasing potential risks in the workplace. Their extensive SDS database is available in various languages and may be accessed any time, anywhere.


  • Document storage
  • Inventory management
  • Chemical labeling

What is Safety Data Sheet Software?

Safety data sheet software is a crucial digital tool intended for laboratories or any facility that uses chemicals and is used to protect the health and safety of its personnel. This stores detailed information about chemicals, including their physical properties, possible health and environmental risks, and safety precautions for handling, storage, transportation, and disposal. This also provides guidelines regarding personal protective equipment (PPE) use, first aid procedures, and clean-up protocols, to name a few.


Safety data sheets (SDS) are incredibly consequential in ensuring the health and safety of the personnel in industries that work with chemicals and other toxic substances. Using a digital system to store and organize this information is crucial for numerous reasons. Here are some:

  • Prepares workers in case of emergencies – Opening cabinets and sifting through alphabetically arranged folders to find the information needed is hardly efficient or safe in emergencies. With electronic SDS stored on-premise or via the cloud, you can quickly access the document in seconds on your laptop or your phone.
  • Provides detailed information that can be easily updated – There is no doubt that traditional (paper-based) safety data sheets are prepared with meticulous care. However, workers find it labor-intensive and time-consuming to make alterations when there are new scientific data or regulatory changes about a particular compound. With SDS software, the task can be accomplished in minutes and immediately disseminated to all relevant personnel.
  • Facilitates safe storage, disposal, and transportation – Aside from the fact that you can easily share this digital document with third-party suppliers (e.g., special warehouses, logistics providers, disposal sites, etc.), you can also track and monitor the activities in real-time, ensuring that these chemicals are in safe hands at all times.
  • Manages risks better – Working with chemicals is incredibly dangerous, but it has been proven time and again that jobs are much safer when digital solutions are integrated into the operations. This is made possible with features like sensors, barcodes on labels, quick incident reporting, and pre-assigned actions.
  • Ensures compliance – According to numerous regulatory bodies, SDS must be readily available to employees in any workplace that use or handle chemicals. With instantly generated reports, a common feature of computerized systems, companies can prove they abide by OSHA mandates and similar regulations in countries like Canada or the UK.

Key Features

One misconception about safety data sheet software is that it is merely a data repository of chemicals used by companies. Enumerated below are its indispensable features, proving that this is a must-have in your workplace.

  • Database of automatically generated documents and classification
  • Central repository with user-defined workflows and role-based access
  • Customizable SDS for updates
  • Inventory monitoring
  • Report generation with analytics
  • Inspection and audit management
  • Training and instructional modules with exposure scenarios
  • Communication with alerts and notifications
  • Mobile accessibility
  • Offline capabilities

Selecting the Right Safety Data Sheet Software

All seven digital platforms mentioned above will be advantageous to your workplace and employees. Take a quick look at all of them below before you make your final decision:

Safety Data Sheet Software Free Version Paid Plan Mobile App
SafetyCulture Yes $24/user/month* Yes
SpheraCloud No Available upon registration Yes
BackPack by Chemwatch No Available upon request Yes
VelocityEHS No Available upon registration Yes
Labelmaster No Available upon request No
3E Protect No Available upon request Yes

* billed annually

Eunice Arcilla Caburao
Article by

Eunice Arcilla Caburao

SafetyCulture Content Contributor
Eunice Caburao is a content contributor for SafetyCulture. A registered nurse, theater stage manager, Ultimate Frisbee athlete, and mother, she has written a wide range of topics for over a decade. Eunice draws upon her rich, multidisciplinary background to create informative articles about emerging topics on health, safety, and workplace efficiency.